Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation

The myoepithelial (MEP) lineage of human breast comprises bipotent and multipotent progenitors in ducts and terminal duct lobular units (TDLUs). We here assess whether this heterogeneity impacts on oncogenic PIK3CA transformation. Single cell RNA sequencing (scRNA-seq) and multicolor imaging reveal...

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Detalles Bibliográficos
Autores principales: Goldhammer, Nadine, Kim, Jiyoung, Villadsen, René, Rønnov-Jessen, Lone, Petersen, Ole William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913783/
https://www.ncbi.nlm.nih.gov/pubmed/35273332
http://dx.doi.org/10.1038/s42003-022-03161-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913783/
https://www.ncbi.nlm.nih.gov/pubmed/35273332
http://dx.doi.org/10.1038/s42003-022-03161-x

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