The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter

The human DEAD-box protein 3 (DDX3) has been reported as a positive regulator and functions in the induction of type I interferon signaling. We elucidated the function of DDX3 in the positive regulation of IFNB production in non-pDC cells. We found that DDX3 regulates virus-induced activation of IFN...

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Detalles Bibliográficos
Autores principales: Saikruang, Wilaiporn, Ang Yan Ping, Lena, Abe, Hiroto, Kasumba, Dacquin M., Kato, Hiroki, Fujita, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913847/
https://www.ncbi.nlm.nih.gov/pubmed/35273248
http://dx.doi.org/10.1038/s41598-022-07876-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913847/
https://www.ncbi.nlm.nih.gov/pubmed/35273248
http://dx.doi.org/10.1038/s41598-022-07876-z

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