Cargando…
The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter
The human DEAD-box protein 3 (DDX3) has been reported as a positive regulator and functions in the induction of type I interferon signaling. We elucidated the function of DDX3 in the positive regulation of IFNB production in non-pDC cells. We found that DDX3 regulates virus-induced activation of IFN...
Autores principales: | Saikruang, Wilaiporn, Ang Yan Ping, Lena, Abe, Hiroto, Kasumba, Dacquin M., Kato, Hiroki, Fujita, Takashi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913847/ https://www.ncbi.nlm.nih.gov/pubmed/35273248 http://dx.doi.org/10.1038/s41598-022-07876-z |
Ejemplares similares
-
Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages
por: Ren, Wenhui, et al.
Publicado: (2017) -
Author Correction: Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages
por: Ren, Wenhui, et al.
Publicado: (2020) -
Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression
por: Schwanke, Hella, et al.
Publicado: (2020) -
The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes
por: Schwanke, Hella, et al.
Publicado: (2023) -
Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter
por: Sun, Donghao, et al.
Publicado: (2018)