Homologous Recombination Deficiency: Concepts, Definitions, and Assays

BACKGROUND: Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway. Loss-of-function genes involved in this pathway can sensitize tumors to poly(a...

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Detalles Bibliográficos
Autores principales: Stewart, Mark D, Merino Vega, Diana, Arend, Rebecca C, Baden, Jonathan F, Barbash, Olena, Beaubier, Nike, Collins, Grace, French, Tim, Ghahramani, Negar, Hinson, Patsy, Jelinic, Petar, Marton, Matthew J, McGregor, Kimberly, Parsons, Jerod, Ramamurthy, Lakshman, Sausen, Mark, Sokol, Ethan S, Stenzinger, Albrecht, Stires, Hillary, Timms, Kirsten M, Turco, Diana, Wang, Iris, Williams, J Andrew, Wong-Ho, Elaine, Allen, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Cancer Diagnostics and Molecular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914493/
https://www.ncbi.nlm.nih.gov/pubmed/35274707
http://dx.doi.org/10.1093/oncolo/oyab053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914493/
https://www.ncbi.nlm.nih.gov/pubmed/35274707
http://dx.doi.org/10.1093/oncolo/oyab053

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