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Dopamine neuron stimulation induces context-dependent abnormal involuntary movements in healthy rats

With continued levodopa treatment, most patients with Parkinson disease (PD) develop levodopa-induced dyskinesias (LIDs)—abnormal involuntary movements (AIMs) characterized primarily by chorea. Clinically, LIDs depend on nigrostriatal degeneration and sensitization to repeated levodopa doses. Howeve...

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Detalles Bibliográficos
Autores principales: Hunter, Julia, Bova, Alexandra, Stevens, Andrew, Leventhal, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8914546/
https://www.ncbi.nlm.nih.gov/pubmed/35281727
http://dx.doi.org/10.1016/j.isci.2022.103974