MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s disease

BACKGROUND: Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the disease. In addition, MT5-MMP defic...

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Detalles Bibliográficos
Autores principales: Pilat, Dominika, Paumier, Jean-Michel, García-González, Laura, Louis, Laurence, Stephan, Delphine, Manrique, Christine, Khrestchatisky, Michel, Di Pasquale, Eric, Baranger, Kévin, Rivera, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915472/
https://www.ncbi.nlm.nih.gov/pubmed/35277173
http://dx.doi.org/10.1186/s12974-022-02407-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915472/
https://www.ncbi.nlm.nih.gov/pubmed/35277173
http://dx.doi.org/10.1186/s12974-022-02407-z

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