Cargando…

MT5-MMP promotes neuroinflammation, neuronal excitability and Aβ production in primary neuron/astrocyte cultures from the 5xFAD mouse model of Alzheimer’s disease

BACKGROUND: Membrane-type matrix metalloproteinase 5 (MT5-MMP) deficiency in the 5xFAD mouse model of Alzheimer's disease (AD) reduces brain neuroinflammation and amyloidosis, and prevents deficits in synaptic activity and cognition in prodromal stages of the disease. In addition, MT5-MMP defic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pilat, Dominika, Paumier, Jean-Michel, García-González, Laura, Louis, Laurence, Stephan, Delphine, Manrique, Christine, Khrestchatisky, Michel, Di Pasquale, Eric, Baranger, Kévin, Rivera, Santiago
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915472/ https://www.ncbi.nlm.nih.gov/pubmed/35277173 http://dx.doi.org/10.1186/s12974-022-02407-z

Ejemplares similares

MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro
por: Baranger, Kévin, et al.
Publicado: (2017)

Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer’s disease: evidence for a pro-amyloidogenic role of MT1-MMP
por: Py, Nathalie A., et al.
Publicado: (2014)

Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
por: van Gijsel-Bonnello, Manuel, et al.
Publicado: (2017)

Correction: Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine
por: van Gijsel-Bonnello, Manuel, et al.
Publicado: (2018)

MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?
por: Baranger, Kévin, et al.
Publicado: (2016)

Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP
por: García-González, Laura, et al.
Publicado: (2019)

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease
por: Baranger, Kévin, et al.
Publicado: (2015)

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease
por: Landel, Véréna, et al.
Publicado: (2014)

Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer’s Disease Model Mice
por: Nguyen, Vu Thu Thuy, et al.
Publicado: (2021)

The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
por: Michael, Johanna, et al.
Publicado: (2021)

Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
por: Rodríguez-Urgellés, Ened, et al.
Publicado: (2022)

Area-Specific Alterations of Synaptic Plasticity in the 5XFAD Mouse Model of Alzheimer’s Disease: Dissociation between Somatosensory Cortex and Hippocampus
por: Crouzin, Nadine, et al.
Publicado: (2013)

Decanoic Acid Rescues Differences in AMPA-Mediated Calcium Rises in Hippocampal CA1 Astrocytes and Neurons in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Abghari, Mina, et al.
Publicado: (2023)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model
por: Chen, Wenqiang, et al.
Publicado: (2023)

Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice
por: Prange-Kiel, Janine, et al.
Publicado: (2016)

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
por: Farfara, Dorit, et al.
Publicado: (2023)

Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice
por: Son, Gowoon, et al.
Publicado: (2021)

The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer’s Disease
por: Skobeleva, Ksenia, et al.
Publicado: (2022)

The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice
por: Ou-Yang, Ming-Hsuan, et al.
Publicado: (2013)

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative
por: Ullah, Rahim, et al.
Publicado: (2020)

Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2020)

Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Dafnis, Ioannis, et al.
Publicado: (2022)

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
por: Wang, Lu, et al.
Publicado: (2016)

Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord
por: Chu, Tak-Ho, et al.
Publicado: (2017)

The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice
por: Jeon, Seong Gak, et al.
Publicado: (2020)

Retinal hyperspectral imaging in the 5xFAD mouse model of Alzheimer’s disease
por: Lim, Jeremiah K. H., et al.
Publicado: (2021)

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
por: Forner, Stefania, et al.
Publicado: (2021)

Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer’s Disease Mouse Model
por: Jeong, Ye Ji, et al.
Publicado: (2021)

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
por: Andersen, Jens V., et al.
Publicado: (2021)

Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice
por: Zhang, Liansheng, et al.
Publicado: (2021)

Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer’s disease animal model
por: Kim, Hyunju, et al.
Publicado: (2020)

Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET
por: Oh, Se Jong, et al.
Publicado: (2018)

Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Lim, Jeremiah K. H., et al.
Publicado: (2020)

Upregulation of Vitamin C Transporter Functional Expression in 5xFAD Mouse Intestine
por: Teafatiller, Trevor, et al.
Publicado: (2021)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
por: Choi, Hee-Jeong, et al.
Publicado: (2022)

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease
por: Jullienne, Amandine, et al.
Publicado: (2023)

Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2
por: Jeon, Seung Ho, et al.
Publicado: (2020)

Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
por: Choi, Moonseok, et al.
Publicado: (2021)

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
por: Crivelli, Simone M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gq8kdbn8n0cu620l59rbr8snte