Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses

BACKGROUND: Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1 encephalitis. Recent reports focus on the significance of thrombomodulin (TM), especially the domain 1, lectin-like domain (TM-LeD), which modulates t...

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Detalles Bibliográficos
Autores principales: Tsai, Meng-Shan, Wang, Li-Chiu, Wu, Hua-Lin, Tzeng, Shun-Fen, Conway, Edward M., Hsu, Sheng-Min, Chen, Shun-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915510/
https://www.ncbi.nlm.nih.gov/pubmed/35277184
http://dx.doi.org/10.1186/s12974-022-02426-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915510/
https://www.ncbi.nlm.nih.gov/pubmed/35277184
http://dx.doi.org/10.1186/s12974-022-02426-w

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