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Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses

BACKGROUND: Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1 encephalitis. Recent reports focus on the significance of thrombomodulin (TM), especially the domain 1, lectin-like domain (TM-LeD), which modulates t...

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Detalles Bibliográficos
Autores principales:	Tsai, Meng-Shan, Wang, Li-Chiu, Wu, Hua-Lin, Tzeng, Shun-Fen, Conway, Edward M., Hsu, Sheng-Min, Chen, Shun-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915510/ https://www.ncbi.nlm.nih.gov/pubmed/35277184 http://dx.doi.org/10.1186/s12974-022-02426-w

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