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Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin

The bioavailability of tetracyclines is markedly decreased when co-administered with antacids, milk, or food containing Ca(2+). Previously, it was suggested that the effective intestinal permeation of tetracycline (TC) was decreased due to Ca(2+) linked mucin binding in the mucosal side. In the pres...

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Detalles Bibliográficos
Autores principales: Yamauchi, Sachika, Inoue, Daisuke, Sugano, Kiyohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915580/
https://www.ncbi.nlm.nih.gov/pubmed/35300369
http://dx.doi.org/10.5599/admet.797