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Permeation characteristics of tetracyclines in parallel artificial membrane permeation assay II: Effect of divalent metal ions and mucin
The bioavailability of tetracyclines is markedly decreased when co-administered with antacids, milk, or food containing Ca(2+). Previously, it was suggested that the effective intestinal permeation of tetracycline (TC) was decreased due to Ca(2+) linked mucin binding in the mucosal side. In the pres...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Association of Physical Chemists
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915580/ https://www.ncbi.nlm.nih.gov/pubmed/35300369 http://dx.doi.org/10.5599/admet.797 |