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Mechanistic modeling of gastrointestinal motility with integrated dissolution for simulating drug absorption
A new computational method – the multiple moving plug (MMP) model – is described to simulate the effect of gastrointestinal motility and dissolution on the pharmacokinetic profile of any given drug. The method is physiologically more consistent with the experimental evidence that fluid exists in dis...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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International Association of Physical Chemists
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915602/ https://www.ncbi.nlm.nih.gov/pubmed/35300303 http://dx.doi.org/10.5599/admet.829 |