A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin

Investigating systemic toxicity in vitro is still a huge challenge. Here, a multi-organ-on-chip approach is presented as a typical case of topical exposure of oral mucosa to metals, which are known to activate the immune system and in turn may result in skin inflammation. Reconstructed human gingiva...

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Detalles Bibliográficos
Autores principales: Koning, Jasper J., Rodrigues Neves, Charlotte T., Schimek, Katharina, Thon, Maria, Spiekstra, Sander W., Waaijman, Taco, de Gruijl, Tanja D., Gibbs, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915798/
https://www.ncbi.nlm.nih.gov/pubmed/35295125
http://dx.doi.org/10.3389/ftox.2021.824825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915798/
https://www.ncbi.nlm.nih.gov/pubmed/35295125
http://dx.doi.org/10.3389/ftox.2021.824825

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