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Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening

Studies in in vivo rodent models have been the accepted approach by regulatory agencies to evaluate potential developmental neurotoxicity (DNT) of chemicals for decades. These studies, however, are inefficient and cannot meet the demand for the thousands of chemicals that need to be assessed for DNT...

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Detalles Bibliográficos
Autores principales: Culbreth, Megan, Nyffeler, Johanna, Willis, Clinton, Harrill, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915842/
https://www.ncbi.nlm.nih.gov/pubmed/35295155
http://dx.doi.org/10.3389/ftox.2021.803987