Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

p53 is primarily known as a downstream transcriptional effector in the DNA damage-response cascade. We report that endogenous p53 rapidly accumulates at DNA damage sites within 2 s of UVA microirradiation. The kinetics of p53 recruitment mimics those of known DNA damage-response proteins, such as Ku...

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Detalles Bibliográficos
Autores principales: Wang, Yu-Hsiu, Ho, Teresa L. F., Hariharan, Anushya, Goh, Hui Chin, Wong, Yao Liang, Verkaik, Nicole S., Lee, May Yin, Tam, Wai Leong, van Gent, Dik C., Venkitaraman, Ashok R., Sheetz, Michael P., Lane, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915893/
https://www.ncbi.nlm.nih.gov/pubmed/35235448
http://dx.doi.org/10.1073/pnas.2113233119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915893/
https://www.ncbi.nlm.nih.gov/pubmed/35235448
http://dx.doi.org/10.1073/pnas.2113233119

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