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Strain and rupture of HIV-1 capsids during uncoating

Viral replication in HIV-1 relies on a fullerene-shaped capsid to transport genetic material deep into the nucleus of an infected cell. Capsid stability is linked to the presence of cofactors, including inositol hexakisphosphates (IP(6)) that bind to pores found in the capsid. Using extensive all-at...

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Detalles Bibliográficos
Autores principales: Yu, Alvin, Lee, Elizabeth M. Y., Briggs, John A. G., Ganser-Pornillos, Barbie K., Pornillos, Owen, Voth, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915963/
https://www.ncbi.nlm.nih.gov/pubmed/35238630
http://dx.doi.org/10.1073/pnas.2117781119