Interlocking activities of DNA polymerase β in the base excision repair pathway

Base excision repair (BER) is a major cellular pathway for DNA damage repair. During BER, DNA polymerase β (Polβ) is hypothesized to first perform gap-filling DNA synthesis by its polymerase activity and then cleave a 5′-deoxyribose-5-phosphate (dRP) moiety via its dRP lyase activity. Through gel el...

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Detalles Bibliográficos
Autores principales: Kumar, Adarsh, Reed, Andrew J., Zahurancik, Walter J., Daskalova, Sasha M., Hecht, Sidney M., Suo, Zucai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915974/
https://www.ncbi.nlm.nih.gov/pubmed/35238634
http://dx.doi.org/10.1073/pnas.2118940119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8915974/
https://www.ncbi.nlm.nih.gov/pubmed/35238634
http://dx.doi.org/10.1073/pnas.2118940119

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