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Human defensin-inspired discovery of peptidomimetic antibiotics

Antibiotics with multiple mechanisms of action and broad-spectrum are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. Combining computational and medicinal chemistry tools, we used the structure of human α-defensin 5 (HD5) to design a class of pept...

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Detalles Bibliográficos
Autores principales: Luo, Gan, Zhang, Jue, Wang, HanBin, Sun, YaQi, Cheng, BaoLi, Xu, ZhiPeng, Zhang, Yan, Li, Hui, Lu, WuYuan, Nemeth, Elizabeta, Ganz, Tomas, Fang, XiangMing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916014/
https://www.ncbi.nlm.nih.gov/pubmed/35238683
http://dx.doi.org/10.1073/pnas.2117283119