N-Acetylcysteine Mitigates Social Dysfunction in a Rat Model of Autism Normalizing Glutathione Imbalance and the Altered Expression of Genes Related to Synaptic Function in Specific Brain Areas

Prenatal exposure to valproic acid (VPA) is a risk factor for autism spectrum disorder (ASD) in humans and it induces autistic-like behaviors in rodents. Imbalances between GABAergic and glutamatergic neurotransmission and increased oxidative stress together with altered glutathione (GSH) metabolism...

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Detalles Bibliográficos
Autores principales: Schiavi, Sara, La Rosa, Piergiorgio, Petrillo, Sara, Carbone, Emilia, D'Amico, Jessica, Piemonte, Fiorella, Trezza, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916240/
https://www.ncbi.nlm.nih.gov/pubmed/35280167
http://dx.doi.org/10.3389/fpsyt.2022.851679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916240/
https://www.ncbi.nlm.nih.gov/pubmed/35280167
http://dx.doi.org/10.3389/fpsyt.2022.851679

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