Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data

Quantifying the activity of gene expression signatures is common in analyses of single-cell RNA sequencing data. Methods originally developed for bulk samples are often used for this purpose without accounting for contextual differences between bulk and single-cell data. More broadly, few attempts h...

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Detalles Bibliográficos
Autores principales: Noureen, Nighat, Ye, Zhenqing, Chen, Yidong, Wang, Xiaojing, Zheng, Siyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916770/
https://www.ncbi.nlm.nih.gov/pubmed/35212622
http://dx.doi.org/10.7554/eLife.71994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916770/
https://www.ncbi.nlm.nih.gov/pubmed/35212622
http://dx.doi.org/10.7554/eLife.71994

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