Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

The cyanobacterial enzyme CylK assembles the cylindrocyclophane natural products by performing two unusual alkylation reactions, forming new carbon–carbon bonds between aromatic rings and secondary alkyl halide substrates. This transformation is unprecedented in biology, and the structure and mechan...

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Detalles Bibliográficos
Autores principales: Braffman, Nathaniel R, Ruskoski, Terry B, Davis, Katherine M, Glasser, Nathaniel R, Johnson, Cassidy, Okafor, C Denise, Boal, Amie K, Balskus, Emily P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916777/
https://www.ncbi.nlm.nih.gov/pubmed/35212625
http://dx.doi.org/10.7554/eLife.75761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8916777/
https://www.ncbi.nlm.nih.gov/pubmed/35212625
http://dx.doi.org/10.7554/eLife.75761

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