Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD(+) balance as a therapeutic strategy

Mitochondrial defects result in dysregulation of metabolomics and energy homeostasis that are detected in upper motor neurons (UMNs) with TDP-43 pathology, a pathology that is predominantly present in both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). While same mitochondrial p...

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Detalles Bibliográficos
Autores principales: Gautam, Mukesh, Gunay, Aksu, Chandel, Navdeep S., Ozdinler, P. Hande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917163/
https://www.ncbi.nlm.nih.gov/pubmed/35277554
http://dx.doi.org/10.1038/s41598-022-08068-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917163/
https://www.ncbi.nlm.nih.gov/pubmed/35277554
http://dx.doi.org/10.1038/s41598-022-08068-5

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