Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum

Dopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine...

Descripción completa

Detalles Bibliográficos
Autores principales: Reynolds, John N. J., Avvisati, Riccardo, Dodson, Paul D., Fisher, Simon D., Oswald, Manfred J., Wickens, Jeffery R., Zhang, Yan-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917208/
https://www.ncbi.nlm.nih.gov/pubmed/35277506
http://dx.doi.org/10.1038/s41467-022-28950-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917208/
https://www.ncbi.nlm.nih.gov/pubmed/35277506
http://dx.doi.org/10.1038/s41467-022-28950-0

Ejemplares similares