Genome-wide pharmacogenetics of anti-drug antibody response to bococizumab highlights key residues in HLA DRB1 and DQB1

In this largest to-date genetic analysis of anti-drug antibody (ADA) response to a therapeutic monoclonal antibody (MAb), genome-wide association was performed for five measures of ADA status among 8844 individuals randomized to bococizumab, which targets PCSK9 for LDL-C lowering and cardiovascular...

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Detalles Bibliográficos
Autores principales: Chasman, Daniel I., Hyde, Craig L., Giulianini, Franco, Danning, Rebecca D., Wang, Ellen Q., Hickling, Timothy, Ridker, Paul M, Loomis, A. Katrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917227/
https://www.ncbi.nlm.nih.gov/pubmed/35277540
http://dx.doi.org/10.1038/s41598-022-07997-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917227/
https://www.ncbi.nlm.nih.gov/pubmed/35277540
http://dx.doi.org/10.1038/s41598-022-07997-5

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