A novel PD-L1-targeted shark V(NAR) single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer

Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies, but it remains challenging to treat solid tumors, mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor microenvironment (TME). The checkpoint molecule progra...

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Detalles Bibliográficos
Autores principales: Li, Dan, English, Hejiao, Hong, Jessica, Liang, Tianyuzhou, Merlino, Glenn, Day, Chi-Ping, Ho, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917269/
https://www.ncbi.nlm.nih.gov/pubmed/35317524
http://dx.doi.org/10.1016/j.omto.2022.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917269/
https://www.ncbi.nlm.nih.gov/pubmed/35317524
http://dx.doi.org/10.1016/j.omto.2022.02.015

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