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Contribution of protein–protein interactions to the endothelial-barrier-stabilizing function of KRIT1

Krev-interaction trapped protein 1 (KRIT1) is an endothelial scaffold protein that promotes adherens junction (AJ) stability. The precise mechanism by which KRIT1 promotes barrier stabilization is unclear. We tested the ability of a panel of KRIT1 constructs containing mutations that inhibit Rap1 bi...

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Detalles Bibliográficos
Autores principales: Swamy, Harsha, Glading, Angela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917353/
https://www.ncbi.nlm.nih.gov/pubmed/34918736
http://dx.doi.org/10.1242/jcs.258816