CPVT-associated calmodulin variants N53I and A102V dysregulate Ca(2+) signalling via different mechanisms

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition that can cause fatal cardiac arrhythmia. Human mutations in the Ca(2+) sensor calmodulin (CaM) have been associated with CPVT susceptibility, suggesting that CaM dysfunction is a key driver of the disease. However...

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Detalles Bibliográficos
Autores principales: Prakash, Ohm, Held, Marie, McCormick, Liam F., Gupta, Nitika, Lian, Lu-Yun, Antonyuk, Svetlana, Haynes, Lee P., Thomas, N. Lowri, Helassa, Nordine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917356/
https://www.ncbi.nlm.nih.gov/pubmed/34888671
http://dx.doi.org/10.1242/jcs.258796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917356/
https://www.ncbi.nlm.nih.gov/pubmed/34888671
http://dx.doi.org/10.1242/jcs.258796

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