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CPVT-associated calmodulin variants N53I and A102V dysregulate Ca(2+) signalling via different mechanisms
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited condition that can cause fatal cardiac arrhythmia. Human mutations in the Ca(2+) sensor calmodulin (CaM) have been associated with CPVT susceptibility, suggesting that CaM dysfunction is a key driver of the disease. However...
Autores principales: | Prakash, Ohm, Held, Marie, McCormick, Liam F., Gupta, Nitika, Lian, Lu-Yun, Antonyuk, Svetlana, Haynes, Lee P., Thomas, N. Lowri, Helassa, Nordine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917356/ https://www.ncbi.nlm.nih.gov/pubmed/34888671 http://dx.doi.org/10.1242/jcs.258796 |
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