SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state

Rhabdomyosarcoma (RMS) is a pediatric muscle sarcoma characterized by expression of the myogenic line-age transcription factors (TFs) MYOD1 and MYOG. Despite high expression of these TFs, RMS cells fail to terminally differentiate, suggesting the presence of factors that alter their functions. Here,...

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Detalles Bibliográficos
Autores principales: Hsu, Jessica Y., Danis, Etienne P., Nance, Stephanie, O’Brien, Jenean H., Gustafson, Annika L., Wessells, Veronica M., Goodspeed, Andrew E., Talbot, Jared C., Amacher, Sharon L., Jedlicka, Paul, Black, Joshua C., Costello, James C., Durbin, Adam D., Artinger, Kristin B., Ford, Heide L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917510/
https://www.ncbi.nlm.nih.gov/pubmed/35108532
http://dx.doi.org/10.1016/j.celrep.2022.110323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917510/
https://www.ncbi.nlm.nih.gov/pubmed/35108532
http://dx.doi.org/10.1016/j.celrep.2022.110323

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