Cargando…

SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state

Rhabdomyosarcoma (RMS) is a pediatric muscle sarcoma characterized by expression of the myogenic line-age transcription factors (TFs) MYOD1 and MYOG. Despite high expression of these TFs, RMS cells fail to terminally differentiate, suggesting the presence of factors that alter their functions. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsu, Jessica Y., Danis, Etienne P., Nance, Stephanie, O’Brien, Jenean H., Gustafson, Annika L., Wessells, Veronica M., Goodspeed, Andrew E., Talbot, Jared C., Amacher, Sharon L., Jedlicka, Paul, Black, Joshua C., Costello, James C., Durbin, Adam D., Artinger, Kristin B., Ford, Heide L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917510/ https://www.ncbi.nlm.nih.gov/pubmed/35108532 http://dx.doi.org/10.1016/j.celrep.2022.110323

Ejemplares similares

PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors
por: Searcy, Madeline B., et al.
Publicado: (2023)

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1‐driven and independent disease‐promoting gene expression in fusion‐positive Rhabdomyosarcoma
por: Sobral, Lays M., et al.
Publicado: (2020)

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma
por: Tenente, Inês M, et al.
Publicado: (2017)

Induction of myogenic differentiation in human rhabdomyosarcoma cells by ionising radiation, N,N-dimethylformamide and their combination.
por: Nicoletti, G., et al.
Publicado: (1992)

Differentiation-dependent chromosomal organization changes in normal myogenic cells are absent in rhabdomyosarcoma cells
por: Ibarra, Joe, et al.
Publicado: (2023)

SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma
por: Hughes, Connor J., et al.
Publicado: (2023)

Differentiation-dependent chromosomal organization changes in normal myogenic cells are absent in rhabdomyosarcoma cells
por: Ibarra, Joe, et al.
Publicado: (2023)

Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation
por: Schilbach, Karin, et al.
Publicado: (2015)

KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma
por: Sobral, Lays Martin, et al.
Publicado: (2020)

BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
por: Laubscher, Dominik, et al.
Publicado: (2021)

Exon skipping in genes encoding lineage-defining myogenic transcription factors in rhabdomyosarcoma
por: Butler, Erin, et al.
Publicado: (2022)

Restoration of p16(INK4A) protein induces myogenic differentiation in RD rhabdomyosarcoma cells
por: Urashima, M, et al.
Publicado: (1999)

Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFβ Signaling is Smad Independent and Requires MEK Activation
por: Miyake, Tetsuaki, et al.
Publicado: (2020)

Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression
por: Skrzypek, Klaudia, et al.
Publicado: (2015)

PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targets
por: Gizaw, Nebeyu Yosef, et al.
Publicado: (2022)

Genome Architecture Mediates Transcriptional Control of Human Myogenic Reprogramming
por: Liu, Sijia, et al.
Publicado: (2018)

OR07-2 Endocrine Response And Resistance Is Driven By Novel Transcriptional Co-Regulator Activity In Invasive Lobular Carcinoma Of The Breast
por: Costello, James, et al.
Publicado: (2022)

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation
por: Anan, Kotaro, et al.
Publicado: (2018)

Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells
por: Wolff, David W., et al.
Publicado: (2018)

Expression of PSMA in tumor neovasculature of high grade sarcomas including synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma and MPNST
por: Heitkötter, Birthe, et al.
Publicado: (2016)

β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia
por: Pydi, Sai P., et al.
Publicado: (2020)

Treatment of an Alveolar Rhabdomyosarcoma Allograft with Recombinant Myxoma Virus and Oclacitinib
por: Ashton, Laura V, et al.
Publicado: (2020)

Retinoic acid induces myogenin synthesis and myogenic differentiation in the rat rhabdomyosarcoma cell line BA-Han-1C
Publicado: (1992)

Modulation of Myogenic Differentiation in a Human Rhabdomyosarcoma Cell Line by a New Derivative of 5‐Fluorouracil (QF‐3602)
por: Marchal, Juan Antonio, et al.
Publicado: (2000)

Rhabdomyosarcoma and Wilms tumors contain a subpopulation of noggin producing, myogenic cells immunoreactive for lens beaded filament proteins
por: Gerhart, Jacquelyn, et al.
Publicado: (2019)

Upregulation of miR181a/miR212 Improves Myogenic Commitment in Murine Fusion-Negative Rhabdomyosarcoma
por: Pozzo, Enrico, et al.
Publicado: (2021)

JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells
por: Walters, Zoë S, et al.
Publicado: (2013)

KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma
por: McCann, Tyler S., et al.
Publicado: (2020)

Anti-oncogenic and pro-myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcoma
por: Di Rocco, Agnese, et al.
Publicado: (2022)

Epidemiology of Undifferentiated Carcinomas
por: Benesch, Matthew G. K., et al.
Publicado: (2022)

Human Rhabdomyosarcoma Cell Lines for Rhabdomyosarcoma Research: Utility and Pitfalls
por: Hinson, Ashley R. P., et al.
Publicado: (2013)

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation
por: Megiorni, Francesca, et al.
Publicado: (2016)

Dickkopf-1 Inhibition Reactivates Wnt/β-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo
por: Giralt, Irina, et al.
Publicado: (2021)

Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer?
por: O’Brien, Jenean, et al.
Publicado: (2009)

MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line
por: Faggi, Fiorella, et al.
Publicado: (2015)

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells
por: Megiorni, Francesca, et al.
Publicado: (2017)

Reduced B7-H3 expression by PAX3-FOXO1 knockdown inhibits cellular motility and promotes myogenic differentiation in alveolar rhabdomyosarcoma
por: Kanayama, Takuyo, et al.
Publicado: (2021)

Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL
por: Skrzypek, Klaudia, et al.
Publicado: (2021)

Myogenic Reprogramming of Bone Marrow Derived Cells in a W(41)Dmd(mdx) Deficient Mouse Model
por: Walsh, Stuart, et al.
Publicado: (2011)

Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells
por: Ito, Naoki, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4t3954e3u8ulkdu9c2g58pcdvk