Cargando…

Deep learning-driven prediction of drug mechanism of action from large-scale chemical-genetic interaction profiles

MOTIVATION: Chemical–genetic interaction profiling is a genetic approach that quantifies the susceptibility of a set of mutants depleted in specific gene product(s) to a set of chemical compounds. With the recent advances in artificial intelligence, chemical–genetic interaction profiles (CGIPs) can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Chengyou, Hogan, Andrew M., Sturm, Hunter, Khan, Mohd Wasif, Islam, Md. Mohaiminul, Rahman, A. S. M. Zisanur, Davis, Rebecca, Cardona, Silvia T., Hu, Pingzhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917716/ https://www.ncbi.nlm.nih.gov/pubmed/35279211 http://dx.doi.org/10.1186/s13321-022-00596-6

Ejemplares similares

A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery
por: Rahman, A. S. M. Zisanur, et al.
Publicado: (2022)

Deep clustering of small molecules at large-scale via variational autoencoder embedding and K-means
por: Hadipour, Hamid, et al.
Publicado: (2022)

Differential Private Deep Learning Models for Analyzing Breast Cancer Omics Data
por: Islam, Md. Mohaiminul, et al.
Publicado: (2022)

A deep neural network based regression model for triglyceride concentrations prediction using epigenome-wide DNA methylation profiles
por: Islam, Md. Mohaiminul, et al.
Publicado: (2018)

An integrative deep learning framework for classifying molecular subtypes of breast cancer
por: Mohaiminul Islam, Md., et al.
Publicado: (2020)

A Maximum Flow-Based Approach to Prioritize Drugs for Drug Repurposing of Chronic Diseases
por: Islam, Md. Mohaiminul, et al.
Publicado: (2021)

ABT-MPNN: an atom-bond transformer-based message-passing neural network for molecular property prediction
por: Liu, Chengyou, et al.
Publicado: (2023)

Identification of putative essential protein domains from high-density transposon insertion sequencing
por: Rahman, A. S. M. Zisanur, et al.
Publicado: (2022)

Profiling cell envelope-antibiotic interactions reveals vulnerabilities to β-lactams in a multidrug-resistant bacterium
por: Hogan, Andrew M., et al.
Publicado: (2023)

Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis
por: O’Neil, Liam J., et al.
Publicado: (2021)

Deep-ocean mixing driven by small-scale internal tides
por: Vic, Clément, et al.
Publicado: (2019)

Bioinformatics driven discovery of small molecule compounds that modulate the FOXM1 and PPARA pathway activities in breast cancer
por: Huang, Shujun, et al.
Publicado: (2022)

Physico-chemical characteristics of gamma-irradiated gelatin
por: Islam, Md. Minhajul, et al.
Publicado: (2014)

Prediction and optimization of properties of concrete containing crushed stone dust and nylon fiber using response surface methodology
por: Mita, Ayesha Ferdous, et al.
Publicado: (2023)

Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles
por: Wang, Rong-Lin, et al.
Publicado: (2016)

Association Analysis of Deep Genomic Features Extracted by Denoising Autoencoders in Breast Cancer
por: Liu, Qian, et al.
Publicado: (2019)

Characterization of Supragingival Plaque and Oral Swab Microbiomes in Children With Severe Early Childhood Caries
por: de Jesus, Vivianne Cruz, et al.
Publicado: (2021)

Child drownings in Bangladesh: need for action
por: Hossain, Md. Jamal, et al.
Publicado: (2022)

Combating Covid-19 using machine learning and deep learning: Applications, challenges, and future perspectives
por: Paul, Showmick Guha, et al.
Publicado: (2023)

Chemical composition and pharmacological activities of Pisum sativum
por: Zilani, Md Nazmul Hasan, et al.
Publicado: (2017)

Radiogenomic association of deep MR imaging features with genomic profiles and clinical characteristics in breast cancer
por: Liu, Qian, et al.
Publicado: (2023)

Nanostructured Hybrid Hydrogels for Solar-Driven Clean Water Harvesting from the Atmosphere
por: Uddin, Md. Nizam, et al.
Publicado: (2022)

The Upsurge of Diarrhea Amid COVID-19 Pandemic Makes Matter Worse in Bangladesh: A Call to Action
por: Rahman, Smaranika, et al.
Publicado: (2022)

Automated Counting of Cancer Cells by Ensembling Deep Features
por: Liu, Qian, et al.
Publicado: (2019)

Automated Detection and Characterization of Colon Cancer with Deep Convolutional Neural Networks
por: Hasan, Md Imran, et al.
Publicado: (2022)

Deep Learning–Driven Automated Detection of COVID-19 from Radiography Images: a Comparative Analysis
por: Rahman, Sejuti, et al.
Publicado: (2021)

Predicting the strength of concrete made with stone dust and nylon fiber using artificial neural network
por: Ray, Sourav, et al.
Publicado: (2022)

Deep learning-based automatic action extraction from structured chemical synthesis procedures
por: Vaškevičius, Mantas, et al.
Publicado: (2023)

Data-driven information for action
por: Wulff, Kristin, et al.
Publicado: (2023)

Scaling up nanoscale water-driven energy conversion into evaporation-driven engines and generators
por: Chen, Xi, et al.
Publicado: (2015)

Deep graph embedding for prioritizing synergistic anticancer drug combinations
por: Jiang, Peiran, et al.
Publicado: (2020)

Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases
por: Mahmud, Aar Rafi, et al.
Publicado: (2023)

Hunger improves reinforcement-driven but not planned action
por: van Swieten, Maaike M.H., et al.
Publicado: (2021)

Multi-Stage Classification of Retinal OCT Using Multi-Scale Ensemble Deep Architecture
por: Akinniyi, Oluwatunmise, et al.
Publicado: (2023)

Antibiotic Prescribing Practices for Treating COVID-19 Patients in Bangladesh
por: Mondal, Utpal Kumar, et al.
Publicado: (2022)

Knowledge, attitudes, and practices toward the novel coronavirus among Bangladeshis: Implications for mitigation measures
por: Paul, Alak, et al.
Publicado: (2020)

Podosome-Driven Defect Development in Lamellar Bone under the Conditions of Senile Osteoporosis Observed at the Nanometer Scale
por: Simon, Paul, et al.
Publicado: (2021)

Enhancing protein inter-residue real distance prediction by scrutinising deep learning models
por: Rahman, Julia, et al.
Publicado: (2022)

Status of deep learning for EEG-based brain–computer interface applications
por: Hossain, Khondoker Murad, et al.
Publicado: (2023)

A self-knowledge distillation-driven CNN-LSTM model for predicting disease outcomes using longitudinal microbiome data
por: Fung, Daryl L X, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lqjpurol6uu1q39uuh3gtmhsdk