A single low dose of primaquine is safe and sufficient to reduce transmission of Plasmodium falciparum gametocytes regardless of cytochrome P450 2D6 enzyme activity in Bagamoyo district, Tanzania

BACKGROUND: Primaquine is a pro-drug and its active metabolite is potent against mature Plasmodium falciparum gametocytes. Primaquine is metabolized by a highly polymorphic cytochrome P450 2D6 (CYP2D6) enzyme. Mutations in the gene encoding this enzyme may lead to impaired primaquine activity. This...

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Detalles Bibliográficos
Autores principales: Mwaiswelo, Richard Owden, Ngasala, Billy, Msolo, Dominick, Kweka, Eliningaya, Mmbando, Bruno P., Mårtensson, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917764/
https://www.ncbi.nlm.nih.gov/pubmed/35279143
http://dx.doi.org/10.1186/s12936-022-04100-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917764/
https://www.ncbi.nlm.nih.gov/pubmed/35279143
http://dx.doi.org/10.1186/s12936-022-04100-1

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