Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells

OBJECTIVE: Cervical cancer (CC) is a prevalent cancer in women. Hypoxia plays a critical role in CC cell ferroptosis resistance. This study explored the mechanism of hypoxia in CC cell ferroptosis resistance by regulating HIF1α/KDM4A/H3K9me3. METHODS: Cultured SiHa and Hela cells were exposed to CoC...

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Detalles Bibliográficos
Autores principales: Xiong, Jing, Nie, Meifang, Fu, Chun, Chai, Xiaoshan, Zhang, Yongjing, He, Ling, Sun, Shujuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917951/
https://www.ncbi.nlm.nih.gov/pubmed/35287356
http://dx.doi.org/10.1155/2022/1608806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917951/
https://www.ncbi.nlm.nih.gov/pubmed/35287356
http://dx.doi.org/10.1155/2022/1608806

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