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Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study
OBJECTIVE: To determine a safe dose of clonidine (CLON) to be used in infants with hypoxic ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). STUDY DESIGN: A pilot prospective study was performed to determine the effect of CLON on autonomic parameters, the pharmacokinetics (PK) o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917970/ https://www.ncbi.nlm.nih.gov/pubmed/34531532 http://dx.doi.org/10.1038/s41372-021-01151-1 |
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author | Gauda, Estelle B Chavez-Valdez, Raul Northington, Frances J Lee, Carlton KK Rudek, Michelle A Guglieri-Lopez, Beatriz Ivaturi, Vijay |
author_facet | Gauda, Estelle B Chavez-Valdez, Raul Northington, Frances J Lee, Carlton KK Rudek, Michelle A Guglieri-Lopez, Beatriz Ivaturi, Vijay |
author_sort | Gauda, Estelle B |
collection | PubMed |
description | OBJECTIVE: To determine a safe dose of clonidine (CLON) to be used in infants with hypoxic ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). STUDY DESIGN: A pilot prospective study was performed to determine the effect of CLON on autonomic parameters, the pharmacokinetics (PK) of CLON, and the amount of morphine (MOR) given “as needed” for shivering and agitation in a cohort of infants (n=12) with HIE undergoing TH compared to a historical control group (n=28). RESULTS: The CLON group received less “as needed” MOR than the MOR-only group for agitation/shivering (p < 0.001), and the CLON vs MOR-only group spent 92% vs 79% of cooling time at the target core body temperature (CBT; p = 0.03, CLON vs MOR). CONCLUSIONS: Intravenous CLON (1mcg/kg Q8h) is well tolerated in infants treated with TH for HIE. CLON stabilizes CBT in the ideal range during cooling which may be optimal for neuroprotection. |
format | Online Article Text |
id | pubmed-8917970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-89179702022-03-16 Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study Gauda, Estelle B Chavez-Valdez, Raul Northington, Frances J Lee, Carlton KK Rudek, Michelle A Guglieri-Lopez, Beatriz Ivaturi, Vijay J Perinatol Article OBJECTIVE: To determine a safe dose of clonidine (CLON) to be used in infants with hypoxic ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). STUDY DESIGN: A pilot prospective study was performed to determine the effect of CLON on autonomic parameters, the pharmacokinetics (PK) of CLON, and the amount of morphine (MOR) given “as needed” for shivering and agitation in a cohort of infants (n=12) with HIE undergoing TH compared to a historical control group (n=28). RESULTS: The CLON group received less “as needed” MOR than the MOR-only group for agitation/shivering (p < 0.001), and the CLON vs MOR-only group spent 92% vs 79% of cooling time at the target core body temperature (CBT; p = 0.03, CLON vs MOR). CONCLUSIONS: Intravenous CLON (1mcg/kg Q8h) is well tolerated in infants treated with TH for HIE. CLON stabilizes CBT in the ideal range during cooling which may be optimal for neuroprotection. 2022-03 2021-09-16 /pmc/articles/PMC8917970/ /pubmed/34531532 http://dx.doi.org/10.1038/s41372-021-01151-1 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Gauda, Estelle B Chavez-Valdez, Raul Northington, Frances J Lee, Carlton KK Rudek, Michelle A Guglieri-Lopez, Beatriz Ivaturi, Vijay Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
title | Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
title_full | Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
title_fullStr | Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
title_full_unstemmed | Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
title_short | Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
title_sort | clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917970/ https://www.ncbi.nlm.nih.gov/pubmed/34531532 http://dx.doi.org/10.1038/s41372-021-01151-1 |
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