Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing

CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various disorders by downregulation of related gene expression. Here, we tested this RNA-editing approach on Beethoven (Bth) mice, an animal model for human DFNA36 due...

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Detalles Bibliográficos
Autores principales: Zheng, Ziwen, Li, Guo, Cui, Chong, Wang, Fang, Wang, Xiaohan, Xu, Zhijiao, Guo, Huiping, Chen, Yuxin, Tang, Honghai, Wang, Daqi, Huang, Mingqian, Chen, Zheng-Yi, Huang, Xingxu, Li, Huawei, Li, Geng-Lin, Hu, Xiaoxiang, Shu, Yilai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918553/
https://www.ncbi.nlm.nih.gov/pubmed/35283480
http://dx.doi.org/10.1038/s41392-022-00893-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918553/
https://www.ncbi.nlm.nih.gov/pubmed/35283480
http://dx.doi.org/10.1038/s41392-022-00893-4

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