Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases

(R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke. To prepare (R)-pCPED with high enantiomeric excess (ee (p)) and yield via the enantioconvergent hydrolysis of racemic styrene oxide (r...

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Detalles Bibliográficos
Autores principales: Zhang, Dong, Lei, Yuqing, Wang, Tingting, Lin, Wenqian, Chen, Xingyi, Wu, Minchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918725/
https://www.ncbi.nlm.nih.gov/pubmed/35295651
http://dx.doi.org/10.3389/fbioe.2022.824300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918725/
https://www.ncbi.nlm.nih.gov/pubmed/35295651
http://dx.doi.org/10.3389/fbioe.2022.824300

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