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Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases
(R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke. To prepare (R)-pCPED with high enantiomeric excess (ee (p)) and yield via the enantioconvergent hydrolysis of racemic styrene oxide (r...
Autores principales: | Zhang, Dong, Lei, Yuqing, Wang, Tingting, Lin, Wenqian, Chen, Xingyi, Wu, Minchen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918725/ https://www.ncbi.nlm.nih.gov/pubmed/35295651 http://dx.doi.org/10.3389/fbioe.2022.824300 |
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