Cargando…

Decoding the Role of Astrocytes in the Entorhinal Cortex in Alzheimer’s Disease Using High-Dimensional Single-Nucleus RNA Sequencing Data and Next-Generation Knowledge Discovery Methodologies: Focus on Drugs and Natural Product Remedies for Dementia

Introduction: Alzheimer’s disease (AD) is a major cause of the development of cognitive decline and dementia. AD and associated dementias (ADRD) are the major contributors to the enormous burden of morbidity and mortality worldwide. To date, there are no robust therapies to alleviate or cure this de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pushparaj, Peter Natesan, Kalamegam, Gauthaman, Wali Sait, Khalid Hussain, Rasool, Mahmood
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918735/ https://www.ncbi.nlm.nih.gov/pubmed/35295737 http://dx.doi.org/10.3389/fphar.2021.720170

Ejemplares similares

Exploration of potential molecular mechanisms and genotoxicity of anti-cancer drugs using next generation knowledge discovery methods
por: Pushparaj, Peter Natesan, et al.
Publicado: (2023)

Role of the antineoplastic drug bleomycin based on toxicogenomic-DNA damage inducing (TGx-DDI) genomic biomarkers data: A meta-analysis
por: Pushparaj, Peter Natesan, et al.
Publicado: (2023)

Cytokines secreted by human Wharton's jelly stem cells inhibit the proliferation of ovarian cancer (OVCAR3) cells in vitro
por: Kalamegam, Gauthaman, et al.
Publicado: (2019)

Primary ovarian cancer cell inhibition by human Wharton's Jelly stem cells (hWJSCs): Mapping probable mechanisms and targets using systems oncology
por: Kalamegam, Gauthaman, et al.
Publicado: (2015)

Human Wharton's Jelly Stem Cell (hWJSC) Extracts Inhibit Ovarian Cancer Cell Lines OVCAR3 and SKOV3 in vitro by Inducing Cell Cycle Arrest and Apoptosis
por: Kalamegam, Gauthaman, et al.
Publicado: (2018)

Corrigendum: Human Wharton’s Jelly stem cell (hWJSC) extracts inhibit ovarian cancer cell lines OVCAR3 and SKOV3 in vitro by inducing cell cycle arrest and apoptosis
por: Kalamegam, Gauthaman, et al.
Publicado: (2023)

Editorial: Methods and application in integrative and regenerative pharmacology: 2021
por: Pushparaj, Peter Natesan, et al.
Publicado: (2022)

Integration of palliative care in the management of oral squamous cell carcinoma
por: Sridhar, Republica, et al.
Publicado: (2023)

Disease associated cellular machinery in anaphylaxis – And the de novo paradigm shift
por: Pushparaj, Peter Natesan, et al.
Publicado: (2015)

Deciphering the Association of Cytokines, Chemokines, and Growth Factors in Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Using an ex vivo Osteochondral Culture System
por: Jafri, Mohammad Alam, et al.
Publicado: (2020)

Role of Oxidative Stress and the Identification of Biomarkers Associated With Thyroid Dysfunction in Schizophrenics
por: Rasool, Mahmood, et al.
Publicado: (2021)

Array comparative genomic hybridization based identification of key genetic alterations at 2p21-p16.3 (MSH2, MSH6, EPCAM), 3p23-p14.2 (MLH1), 7p22.1 (PMS2) and 1p34.1-p33 (MUTYH) regions in hereditary non polyposis colorectal cancer (Lynch syndrome) in the Kingdom of Saudi Arabia
por: Rasool, Mahmood, et al.
Publicado: (2020)

Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
por: Khan, Fazal, et al.
Publicado: (2016)

Antiatherogenic Effects of Quercetin in the THP-1 Macrophage Model In Vitro, With Insights Into Its Signaling Mechanisms Using In Silico Analysis
por: Huwait, Etimad A., et al.
Publicado: (2021)

Thymoquinone (TQ) Inhibits Inflammation and Migration of THP-1 Macrophages: Mechanistic Insights into the Prevention of Atherosclerosis Using In-Vitro and In-Silico Analysis
por: Huwait, Etimad, et al.
Publicado: (2022)

Molecular docking of resveratrol with known protein structures as well as high-throughput meta-data analyses uncork the “French Paradox” and its potential “Druggable” targets in humans
por: Pushparaj, Peter Natesan, et al.
Publicado: (2014)

Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells
por: Abou-Elhamd, Alaa Sayed, et al.
Publicado: (2021)

Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats
por: Khan, Fazal, et al.
Publicado: (2017)

Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease
por: Yeh, Chia-Yu, et al.
Publicado: (2011)

Astrocyte control of the entorhinal cortex‐dentate gyrus circuit: Relevance to cognitive processing and impairment in pathology
por: Di Castro, Maria Amalia, et al.
Publicado: (2021)

Overexpression of CXCL8 gene in Saudi colon cancer patients
por: Rasool, Mahmood, et al.
Publicado: (2021)

Neuronal Plasticity in the Entorhinal Cortex
por: Chapman, C. Andrew, et al.
Publicado: (2008)

Decoding the Role of Sphingosine-1-Phosphate in Asthma and Other Respiratory System Diseases Using Next Generation Knowledge Discovery Platforms Coupled With Luminex Multiple Analyte Profiling Technology
por: Bahlas, Sami, et al.
Publicado: (2020)

Human Wharton’s Jelly Stem Cell Secretions Inhibit Human Leukemic Cell Line K562 in vitro by Inducing Cell Cycle Arrest and Apoptosis
por: Huwaikem, Muneerah A. H., et al.
Publicado: (2021)

Decoding the differential biomarkers of Rheumatoid arthritis and Osteoarthritis: A functional genomics paradigm to design disease specific therapeutics
por: Biswas, Sreyasi, et al.
Publicado: (2011)

Synchronization of entorhinal cortex stellate cells
por: Crotty, Patrick, et al.
Publicado: (2012)

Entorhinal cortex stellate cell synchronization
por: Crotty, Patrick, et al.
Publicado: (2014)

Functional topography of the human entorhinal cortex
por: Navarro Schröder, Tobias, et al.
Publicado: (2015)

Functional subregions of the human entorhinal cortex
por: Maass, Anne, et al.
Publicado: (2015)

Mutational spectrum of BRAF gene in colorectal cancer patients in Saudi Arabia
por: Rasool, Mahmood, et al.
Publicado: (2021)

Architecture of the Entorhinal Cortex A Review of Entorhinal Anatomy in Rodents with Some Comparative Notes
por: Witter, Menno P., et al.
Publicado: (2017)

Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1
por: Vandrey, Brianna, et al.
Publicado: (2022)

Role of tyrosine kinase inhibitor in chronic myeloid leukemia patients with SARS-CoV-2 infection: A narrative Review
por: Asif, Muhammad, et al.
Publicado: (2022)

Postnatal Development of Projections of the Postrhinal Cortex to the Entorhinal Cortex in the Rat
por: Lagartos-Donate, Maria Jose, et al.
Publicado: (2022)

The Role of the Entorhinal Cortex in Extinction: Influences of Aging
por: Bevilaqua, Lia R. M., et al.
Publicado: (2008)

Effects of acetylcholine on neuronal properties in entorhinal cortex
por: Heys, James G., et al.
Publicado: (2012)

Does the entorhinal cortex use the Fourier transform?
por: Orchard, Jeff, et al.
Publicado: (2013)

Entorhinal Cortex Volume in Antipsychotic-naïve Schizophrenia
por: Jose, Sam P., et al.
Publicado: (2012)

The role of the entorhinal cortex in epileptiform activities of the hippocampus
por: Ren, Hui, et al.
Publicado: (2014)

The piriform, perirhinal, and entorhinal cortex in seizure generation
por: Vismer, Marta S., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_o24o7jhla2qttn2c3h1eron78q