The Pharmacological and Structural Basis of the AahII–Na(V)1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody

Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (Na(V)) channels leading to several neuro- and cardiotoxic effects in mammals. The toxin AahII is the most active α-toxin from the North African scorpion Androctonus australis Hector that slows the...

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Detalles Bibliográficos
Autores principales: Hmaidi, Riadh, Ksouri, Ayoub, Benabderrazek, Rahma, Antonietti, Viviane, Sonnet, Pascal, Gautier, Mathieu, Bouhaouala-Zahar, Balkiss, Ouadid-Ahidouch, Halima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918821/
https://www.ncbi.nlm.nih.gov/pubmed/35295326
http://dx.doi.org/10.3389/fphar.2022.821181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918821/
https://www.ncbi.nlm.nih.gov/pubmed/35295326
http://dx.doi.org/10.3389/fphar.2022.821181

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