Cargando…
The Pharmacological and Structural Basis of the AahII–Na(V)1.5 Interaction and Modulation by the Anti-AahII Nb10 Nanobody
Scorpion α-toxins are neurotoxins that target the fast inactivation mechanism of voltage-gated sodium (Na(V)) channels leading to several neuro- and cardiotoxic effects in mammals. The toxin AahII is the most active α-toxin from the North African scorpion Androctonus australis Hector that slows the...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918821/ https://www.ncbi.nlm.nih.gov/pubmed/35295326 http://dx.doi.org/10.3389/fphar.2022.821181 |