Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis

Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on the pulmonary endothelial barrier and metastati...

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Detalles Bibliográficos
Autores principales: Smeda, Marta, Stojak, Marta, Przyborowski, Kamil, Sternak, Magdalena, Suraj-Prazmowska, Joanna, Kus, Kamil, Derszniak, Katarzyna, Jasztal, Agnieszka, Kij, Agnieszka, Kurpinska, Anna, Kieronska-Rudek, Anna, Wojnar-Lason, Kamila, Buczek, Elzbieta, Mohaissen, Tasnim, Chlopicki, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918823/
https://www.ncbi.nlm.nih.gov/pubmed/35295330
http://dx.doi.org/10.3389/fphar.2022.834472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918823/
https://www.ncbi.nlm.nih.gov/pubmed/35295330
http://dx.doi.org/10.3389/fphar.2022.834472

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