A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough

OBJECTIVE: Baclofen is a centrally acting γ-aminobutyric acid type B (GABA(B)) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use. Lesogaberan is a novel peripherally acting GABA(B) agonist, but its eff...

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Detalles Bibliográficos
Autores principales: Badri, Huda, Gibbard, Carmen, Denton, Dimitra, Satia, Imran, Al-Sheklly, Bashar, Dockry, Rachel J., Holt, Kimberley, McGuiness, Kevin, Treadway, Sam, Whorwell, Peter, Houghton, Lesley, Lee, Augustine, Escott, K. Jane, Lee, Theresa, Wilkinson, Greame, Holt, Alison, Canning, Brendan J., Smith, Jacky A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918934/
https://www.ncbi.nlm.nih.gov/pubmed/35295236
http://dx.doi.org/10.1183/23120541.00546-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918934/
https://www.ncbi.nlm.nih.gov/pubmed/35295236
http://dx.doi.org/10.1183/23120541.00546-2021

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