O(6)-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells via its gene promoter DNA hypomethylation

BACKGROUND: O(6)-methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the mispairing base O(6)-methyl-guanine induced by environmental and experimental carcinogens. It can transfer the alkyl group to a cysteine residue in its active site and became inactive. The chemical carci...

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Detalles Bibliográficos
Autores principales: Chen, Yue-Xia, He, Lu-Lu, Xiang, Xue-Ping, Shen, Jing, Qi, Hong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919019/
https://www.ncbi.nlm.nih.gov/pubmed/35321285
http://dx.doi.org/10.4251/wjgo.v14.i3.664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919019/
https://www.ncbi.nlm.nih.gov/pubmed/35321285
http://dx.doi.org/10.4251/wjgo.v14.i3.664

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