DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

DOT1L methylates histone H3 lysine 79 during transcriptional elongation and is stimulated by ubiquitylation of histone H2B lysine 120 (H2BK120ub) in a classical trans-histone crosstalk pathway. Aberrant genomic localization of DOT1L is implicated in mixed lineage leukemia (MLL)-rearranged leukemias,...

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Detalles Bibliográficos
Autores principales: Spangler, Cathy J., Yadav, Satya P., Li, Dongxu, Geil, Carinne N., Smith, Charlotte B., Wang, Gang Greg, Lee, Tae-Hee, McGinty, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919193/
https://www.ncbi.nlm.nih.gov/pubmed/35172132
http://dx.doi.org/10.1016/j.celrep.2022.110369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919193/
https://www.ncbi.nlm.nih.gov/pubmed/35172132
http://dx.doi.org/10.1016/j.celrep.2022.110369

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