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Time‐series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations

The cell stress‐responsive transcription factor p53 influences the expression of its target genes and subsequent cellular responses based in part on its dynamics (changes in level over time). The mechanisms decoding p53 dynamics into subsequent target mRNA and protein dynamics remain unclear. We sys...

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Detalles Bibliográficos
Autores principales: Jiménez, Alba, Lu, Dan, Kalocsay, Marian, Berberich, Matthew J, Balbi, Petra, Jambhekar, Ashwini, Lahav, Galit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919251/
https://www.ncbi.nlm.nih.gov/pubmed/35285572
http://dx.doi.org/10.15252/msb.202110588