Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

The success of small molecule therapeutics that promotes degradation of critical cancer targets has fueled an intense effort to mimic this activity with bispecific molecules called PROTACs (proteolysis targeting chimeras). The simultaneous binding of PROTACs to a ligase and target can induce proximi...

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Detalles Bibliográficos
Autores principales: Luo, Xin, Archibeque, Ivonne, Dellamaggiore, Ken, Smither, Kate, Homann, Oliver, Lipford, James Russell, Mohl, Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
https://www.ncbi.nlm.nih.gov/pubmed/35295813
http://dx.doi.org/10.1016/j.isci.2022.103985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919295/
https://www.ncbi.nlm.nih.gov/pubmed/35295813
http://dx.doi.org/10.1016/j.isci.2022.103985

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