Discovery of Pyridone-Substituted Triazolopyrimidine Dual A(2A)/A(1) AR Antagonists for the Treatment of Ischemic Stroke

[Image: see text] Ischemic stroke is a complex systemic disease characterized by high morbidity, disability, and mortality. The activation of the presynaptic adenosine A(2A) and A(1) receptors modifies a variety of brain insults from excitotoxicity to stroke. Therefore, the discovery of dual A(2A)/A...

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Detalles Bibliográficos
Autores principales: Tang, Mei-Lin, Wen, Zi-Hao, Wang, Jing-Huan, Wang, Mei-Ling, Zhang, Heyanhao, Liu, Xin-Hua, Jin, Lin, Chang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919384/
https://www.ncbi.nlm.nih.gov/pubmed/35295085
http://dx.doi.org/10.1021/acsmedchemlett.1c00599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919384/
https://www.ncbi.nlm.nih.gov/pubmed/35295085
http://dx.doi.org/10.1021/acsmedchemlett.1c00599

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