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Discovery of Pyridone-Substituted Triazolopyrimidine Dual A(2A)/A(1) AR Antagonists for the Treatment of Ischemic Stroke

[Image: see text] Ischemic stroke is a complex systemic disease characterized by high morbidity, disability, and mortality. The activation of the presynaptic adenosine A(2A) and A(1) receptors modifies a variety of brain insults from excitotoxicity to stroke. Therefore, the discovery of dual A(2A)/A...

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Detalles Bibliográficos
Autores principales:	Tang, Mei-Lin, Wen, Zi-Hao, Wang, Jing-Huan, Wang, Mei-Ling, Zhang, Heyanhao, Liu, Xin-Hua, Jin, Lin, Chang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919384/ https://www.ncbi.nlm.nih.gov/pubmed/35295085 http://dx.doi.org/10.1021/acsmedchemlett.1c00599

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