Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity

[Image: see text] Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) with the support of molecular docking studies. The target dicationic or monocationic compounds, which show the guanidium group at different positions of the pyridaz...

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Detalles Bibliográficos
Autores principales: Costas-Lago, María Carmen, Vila, Noemí, Rahman, Adeyemi, Besada, Pedro, Rozas, Isabel, Brea, José, Loza, María Isabel, González-Romero, Elisa, Terán, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919506/
https://www.ncbi.nlm.nih.gov/pubmed/35300077
http://dx.doi.org/10.1021/acsmedchemlett.1c00633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919506/
https://www.ncbi.nlm.nih.gov/pubmed/35300077
http://dx.doi.org/10.1021/acsmedchemlett.1c00633

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