Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures

[Image: see text] Multitarget directed ligands (MTDLs) represent a promising frontier in tackling the complexity of multifactorial pathologies. The synergistic inhibition of monoamine oxidase B (MAO B) and acetylcholinesterase (AChE) is believed to provide a potentiated effect in the treatment of Al...

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Detalles Bibliográficos
Autores principales: Ekström, Fredrik, Gottinger, Andrea, Forsgren, Nina, Catto, Marco, Iacovino, Luca G., Pisani, Leonardo, Binda, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919507/
https://www.ncbi.nlm.nih.gov/pubmed/35300078
http://dx.doi.org/10.1021/acsmedchemlett.2c00001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919507/
https://www.ncbi.nlm.nih.gov/pubmed/35300078
http://dx.doi.org/10.1021/acsmedchemlett.2c00001

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